Bosh sahifa - Mahsulotlar - Inhibitorlar va agonistlar - Epigenetika kutubxonasi - Batafsil

PF06291874 CAS No3a1393124-08-7

Kimyoviy tuzilishi % 3a GCGR-IN-17
CAS No.: 1393124-08-7}

So'rov yuborish

Ta'rif

Chemical Structure : GCGR-IN-17

CAS No.: 1393124-08-7}

GCGR-IN-17}(PF-06291874;PF06291874;PF-6291874)

Katalog Yo'q.% 3a URK-V735 Faqat ishlatilgan lab.

PF06291874 (GCGR-IN-17) is a yuqori potentsiala glucagon retseptor antagonist bilan ki 14 nM for hGCGR.

Biologik faoliyat

PF06291874 (GCGR-IN-17) is a yuqori potentsiala glucagon retseptor antagonist bilan ki 14 nM for hGCGR.
% 0aPF06291874 ko'rsatadi excellent selektivity qarshi a panel of 69 retseptorlari, ion kanallar, uptake saytlar va fermentlar.
% 0aPF06291874 kamaytiradi glucagon-elicited glyukoza ekskursiya in a dose-dep endent manner in rats.
% 0aPF06291874 displeylar past in in vivo tozalash va mukammal oraliq bioavailability in ikkala mushak va itlar.

Fizikokimyoviy xossalari

M.Wt	503.513
Formula	C26H28F3N3O4
CAS No	1393124-08-7
	Qatlam kukun % 7b% 7b0}} degree 3years% 3b 4 daraja 2years	In Solvent % 7b% 7b0}} daraja 6 oy % 7b% 7b0}} daraja 1 oy
Oʻlchanuvchanlik	DMSO% 3a Katta dan or teng 30 mg/mL
Kimyoviy nom	glukagon retseptor antagonistlar-4, N-%[4-} %[(1S){-1-}[3,{5-dimethyl%% 7b{7}}}[4-}}(trifluorometil){{{9%7 d}H-pirazol{-1-}}]fenoksi]butil]butil]benzoyl]-