Ta'rif
Kimyoviy tuzilish % 3a BLU9931
CAS No.: 1538604-68-0}
BLU9931 (BLU% 7b{0}% 7d% 7d)
Katalog Yo'q.% 3a URK-V694
BLU9931 (BLU% 7b{1}}) a kuchli, selektiv, o'zgarmas inhibitor FGFR4 ning IC50 bilan 3 nM, ko'rsatuvlar juda zaif aktivligi FG uchunFR1 (IC{50=591}%nM), FGFR2 (IC{50=493} nM) va FGFR3 (IC{50=150 nM).
Biologik faoliyat
BLU9931 (BLU-9931) a potentsiala, selektiv, qaytmas inhibitor of FGFR4 with IC50 of 3 nM.
% 0aBLU9931 shows koʻrsatuv juda zaif aktiv for FGFR1 (IC50=591 nM), FGFR 2 (IC{{50=493%nM) va FGFR3 (IC{50=150 nM).
% 0aBLU9931 kuchli va tanlab inhibitiflar FGFR4 signalizatsiya va hujayra tarqalish ichida HCC hujayra chiziqlari bilan an faollashtirilgan FGFR4 signalizatsiya yo'li (Huh{{ }} hujayra IC{{50=110%nM, JHH{-7 IC50=20%nM).
% 0aBLU9931 ko'rsatadi ajoyib antitumor faoliyati in sichqonlar ko'taruvchi HCC o'simta ksenograft bu haddan tashqari bosim FGF19.
Fizikokimyoviy xossalari
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M.Wt |
509.384 |
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Formula |
C26H22Cl2N4O3 |
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CAS No |
1538604-68-0 |
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Saqlash |
Qatlam kukun % 7b% 7b0}} degree 3years% 3b 4 daraja 2years |
In Solvent % 7b% 7b0}} daraja 6 oy -20 degree 1 Months |
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Oʻlchanuvchanlik |
17 mg% 2fml in DMSO |
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Kimyoviy nom |
2-Propenamid, N-% 5b2-[[6-}(2,{{{5}d}dichloro}}}d{{}b{}b{{{{{}{}{{{}{}b{{{}}b}{{}b{}}b{}b}{{} 7b{6}},5-}etoksifenil)%{{{8}{8}}}{nazolinyl]amino]]{-3-}}methylfenil]- |
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Maʼlumot
1. Hagel M, et al. Kansert Diskov. 2015 Apr;5(4):424-37.
2. Packer LM, et al. Rak Diskov. 2015 Apr;5(4):355-7.
3. Yamamoto M, et al. Rak Sci. 2018 Mar 13. doi: 10.1111/cas.13569.
URL-V% 7b{1}}COAURL-V% 7b{1}}SDSURL-V% 7b{1}}TDS
Issiq teglar: blu9931 cas no.:1538604-68-0
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